Key Takeaways
- Crohn’s disease is a chronic inflammatory condition that can affect any part of the digestive tract, leading to symptoms such as abdominal pain, diarrhea, fatigue, and weight loss.
- Symptoms often progress over time, and untreated inflammation can result in long-term complications such as strictures, fistulas, and malnutrition.
- Several factors, including genetics, immune responses, and environmental triggers, contribute to the development and flare-ups of Crohn's disease.
- Treatment options range from lifestyle adjustments to advanced infusion therapies such
- as Remicade®, Entyvio®, and Stelara®, which target inflammation and help maintain remission.
- The Infusion Center at Denver Arthritis Clinic provides expert, physician-supported Crohn’s disease infusion therapy in Denver and Lone Tree. Schedule an appointment today to begin personalized care.
What Is Crohn’s Disease?
Crohn’s disease is a form of inflammatory bowel disease (IBD) that causes chronic inflammation in the gastrointestinal (GI) tract. While it most commonly affects the small intestine and colon, Crohn’s can occur anywhere from the mouth to the anus. Because inflammation can penetrate deeply into the intestinal walls, symptoms may persist and be severe.
Although researchers have not identified a single cause, Crohn’s is believed to result from an abnormal immune response that mistakenly attacks the digestive tract. Genetics, environmental factors, and disruptions in gut bacteria may also play a role in how the condition develops.
Causes and Contributing Factors of Crohn’s Disease
The exact cause of Crohn’s disease is unknown, but several factors are known to increase risk or contribute to the onset of inflammation.
1. Immune System Dysfunction
Crohn’s disease is often linked to an overactive immune response. When the immune system misidentifies normal gut bacteria as threats, it triggers inflammation that can become chronic without proper treatment.
2. Genetics
Individuals with a family history of IBD have a higher risk of developing Crohn’s disease. Dozens of genes associated with immune regulation have been linked to Crohn’s, suggesting a strong hereditary component.
3. Environmental Triggers
Environmental influences may play a significant role in flare-ups. These include:
- Smoking
- Chronic stress
- High-fat or processed diets
- Certain medications (such as NSAIDs)
4. Gut Microbiome Changes
An imbalance in the gut’s bacterial population may contribute to inflammation, though researchers are continuing to explore this connection.
Common Symptoms of Crohn’s Disease
Crohn’s disease symptoms can vary widely depending on where inflammation occurs and how severe it becomes. The most frequently reported symptoms include:
- Persistent diarrhea
- Abdominal pain and cramping
- Fatigue and low energy
- Unintended weight loss
- Reduced appetite
- Fever during flares
- Nutrient malabsorption
How Symptoms Progress Over Time
Without proper treatment, Crohn’s symptoms can worsen and lead to complications such as:
- Increased digestive pain
- More frequent stools
- Severe fatigue
- Blood in stools
- Dehydration
- Reduced ability to absorb vitamins and minerals
These changes often develop gradually, making it important for individuals to monitor symptoms and seek medical care if they intensify.
Long-Term Effects of Crohn’s Disease on the Body
Chronic inflammation from Crohn’s can affect more than just digestion. Over time, it may lead to a range of medical complications:
1. Digestive System Damage
- Strictures: Narrowing of the intestines caused by scar tissue buildup
- Fistulas: Abnormal passages that form between organs or through the skin
- Abscesses: Collections of infection that may require medical treatment
2. Malnutrition
Ongoing inflammation can interrupt the body’s ability to absorb nutrients, especially iron, vitamin B12, and essential electrolytes, leading to anemia and weakness.
3. Weight Loss and Muscle Depletion
Patients may lose weight due to pain, poor appetite, or malabsorption.
4. Systemic Health Effects
Crohn’s disease can increase the risk of:
- Joint inflammation
- Eye conditions
- Skin disorders
- Bone density loss
Comprehensive treatment is essential to minimize long-term complications and preserve overall health.
Risk Factors and Triggers for Crohn’s Disease
While anyone can develop Crohn’s disease, certain factors elevate risk:
Major Risk Factors
| Risk Factor | Influence |
|---|---|
| Family history | Higher likelihood due to genetic predisposition |
| Smoking | Strongest controllable risk factor; increases severity |
| Age | Most commonly diagnosed between 15–35 |
| Ethnicity | Some populations have higher risk |
Common Triggers for Flares
- High stress levels
- Infections
- Dietary changes
- Medication side effects
- Poor sleep
Understanding these factors can help individuals anticipate and manage flare-ups more effectively.
Overview of Crohn’s Disease Treatment Options
Crohn’s disease management focuses on reducing inflammation, preventing flare-ups, and maintaining long-term remission. Treatment plans may include lifestyle adjustments, medication, and targeted biologic therapy.
Infusion Therapy for Crohn’s Disease
Infusion therapy plays a vital role for many patients with moderate to severe Crohn’s disease. At The Infusion Center at Denver Arthritis Clinic, several advanced biologic medications are available to treat inflammation directly and help maintain remission.
Common Infusion Options
The following infusion therapies are offered for Crohn’s disease:
Remicade® (Infliximab)
- Blocks specific inflammatory proteins
- Helps reduce abdominal pain and diarrhea
- Supports long-term remission
- Typically administered every 8 weeks after initial doses
Entyvio® (Vedolizumab)
- Targets gut-focused inflammation
- Designed specifically for IBD, including Crohn’s disease and ulcerative colitis
- Helps many patients reach and maintain remission
Stelara® (Ustekinumab)
- Targets proteins that fuel inflammation
- Often used when other treatments have been insufficient
Treatment Features at the Infusion Center
Patients receiving infusion therapy benefit from:
- Physician availability during every treatment
- A 3:1 Registered Nurse ratio for attentive monitoring
- Comfortable amenities, including oversized recliners, Wi-Fi, snacks, and beverages
- Insurance coordination and copay assistance
This supportive environment helps patients remain comfortable and confident throughout their treatment journey.
Personalized Care for Crohn’s Disease in Denver and Lone Tree
Crohn’s disease can deeply impact daily life, but effective treatment, including infusion therapy, helps manage inflammation, reduce symptoms, and improve long-term health. The Infusion Center at Denver Arthritis Clinic provides specialized infusion services designed to support patients with Crohn’s disease at both the Denver (Lowry) and Lone Tree locations.
To explore Crohn’s disease infusion therapy, schedule an appointment with The Infusion Center at Denver Arthritis Clinic and begin personalized treatment focused on your comfort and long-term wellness.
Frequently Asked Questions
What is Crohn’s disease?
Crohn’s disease is a chronic inflammatory condition that affects the digestive tract and can cause abdominal pain, diarrhea, fatigue, and unintended weight loss.
What are the most common Crohn’s disease symptoms?
Typical symptoms include diarrhea, abdominal cramping, reduced appetite, fatigue, weight loss, and nutrient deficiencies.
How is Crohn’s disease diagnosed?
Diagnosis often involves blood tests, stool testing, imaging, and endoscopy performed by a healthcare provider to assess inflammation and rule out other conditions.
What treatment options are available for Crohn’s disease?
Treatment may include dietary adjustments, medication, and biologic infusion therapy. Infusion medications such as Remicade®, Entyvio®, and Stelara® are available at The Infusion Center at Denver Arthritis Clinic.
How does infusion therapy help Crohn’s disease?
Infusion therapies work by blocking inflammatory pathways in the gut, helping reduce symptoms, prevent flare-ups, and support long-term remission.
